Development and Process Optimization of Variables for Preparation of Novel Polymeric Nanoparticles Containing Cromolyn Sodium

The main purpose of this study is developed and drug loaded nanoparticles of azelastine hydrochloride, an antiallergic drug and optimization in terms of chemical properties, drug concentration, polymer concentration, cross‐linking agent and stirring time. Nanoparticles of azelastine hydrochloride were fabricated using chitosan and sodium alginate as polymers by ionotropic pregelation method. Calcium chloride was also included in the formulation for pregelation of sodium alginate. Chitosan and sodium alginate suspension further crosslinked with calcium chloride. Different formulations of nanoparticles were prepared using different concentrations of chitosan, stirringtime of rotation and polymers to drug ratio in the nanoparticles. The average particle size ranged between 232.30 nm to 638.3 nm. Drug entrapment ranged between 70.00%‐92.2%. The result indicated that the drug loaded nanoparticles of azelastine hydrochloride showed optimum particle size, maximum drug entrapment, zeta potential (>30)with drug polymer ratio 05:75, cross‐linking agents 0.5 ml, stirring rate 800 rpm and stirring time 30 min.